ILEAL INTERPOSITION
Ileal Interposition is a laparoscopic operation for control of Type-2 Diabetes in which a long segment of last part of small bowel (Ileum) is cut & joined very close to the stomach. This results in several hormonal changes such as reduced Ghrelin, increased GLP1 and Peptide YY. These hormonal changes results in resolution or long term remission of type 2 diabetes (T2D). Undigested food now first enters Ileum to stimulate increased secretion of incretin (gut) hormone called GLP-1, which stimulates beta cells in pancreas to secrete increase amounts of insulin, provided enough Beta Cell mass is still present in pancreas. Persistent increased GLP-1 secretion increases Beta Cell mass in the long term.
Advantage:
Operation for control of Type-2 diabetes even with normal BMI (Non obese patients)
Disadvantage–
There is slight risk of vitamin and mineral deficiencies.
